My laboratory is dedicated to discerning molecular basis of hormone-dependent cancer development and progression, with a focus on cell cycle and transcriptional control in advanced prostate cancer. I serve as the Chair of the Hilary Koprowski Professor of Cancer Biology at the Thomas Jefferson University, with joint appointments in the Departments of Urology, Radiation Oncology, and Medical Oncology. I am also the Director of the NCI-designated Kimmel Cancer Center. My research interests are dedicated to understanding the mechanisms by which hormone receptor and cell cycle deregulation lead to prostate cancer progression and therapeutic bypass. The overall goal of our research is to utilize this information for successful development of precision medicine, to improve therapeutic outcome through rational therapy delivery. Our studies identifying tumor suppressor and hormone receptor alterations have uncovered new targets for treating advanced disease, and led to development of investigator-initiated, funded clinical trials. I collaborate closely with clinical, translational, and basic researchers.
- Impact of cell cycle dysregulation on prostate cancer development and progression
- DNA repair-alterations in human cancers
- Hormone signaling in prostate cancer