Publications

Contact

Name: Hideko Kaji, PhD
Position: Professor

1020 Locust Street
JAH 456A
Philadelphia, PA 19107

Telephone: 215-503-6547

Highlighted Publications

Chen, Y., Kaji, A., Kaji, H., Cooperman, B.S “The kinetic mechanism of bacterial ribosome recycling” Nucleic Acid Research 45(17) : 10169-10177, 2017

Iwakura et al. 2017 “Chemical and structural characterization of a model Post-Termination Complex (PoTC) for the ribosome recycling reaction: Evidence for the release of the mRNA by RRF and EF-G” Plos1, volume 12 issue 7 page e0177972, 2017

Recent Publications

The kinetic mechanism of bacterial ribosome recycling

Chemical and structural characterization of a model Post-Termination Complex (PoTC) for the ribosome recycling reaction: Evidence for the release of the mRNA by RRF and EF-G

Correlated measurement of endogenous ATE1 activity on native acceptor proteins in tissues and cultured cells to detect cellular aging

Recollection of how we came across the protein modification with amino acids by Aminoacyl tRNA-protein transferase

Possible steps of complete disassembly of post-termination complex by yeast eEF3 deduced from inhibition by translocation inhibitors

Global cellular regulation including cardiac function by post-translational protein arginylation

Protein synthesis factors (RF1, RF2, RF3, RRF, and tmRNA) and peptidyl-tRNA hydrolase rescue stalled ribosomes at sense codons

Structural insights into initial and intermediate steps of the ribosome-recycling process

Protein modification by arginylation

Ribosome recycling step in yeast cytoplasmic protein synthesis is catalyzed by eEF3 and ATP

The role of GTP in transient splitting of 70S ribosomes by RRF (ribosome recycling factor) and EF-G (elongation factor G)

Structural Insights into Ribosome Recycling Factor Interactions with the 70S Ribosome

Erratum: Novel activity of eukaryotic translocase, eEF2: Dissociation of the 80S ribosome into subunits with ATP but not with GTP (Nucleic Acids Research (2007) vol. 35 (4597-4607))

Structural basis for aminoglycoside inhibition of bacterial ribosome recycling

Progression of the Ribosome Recycling Factor through the Ribosome Dissociates the Two Ribosomal Subunits

Novel activity of eukaryotic translocase, eEF2: Dissociation of the 80S ribosome into subunits with ATP but not with GTP

Ribosome recycling: An essential process of protein synthesis

Inhibition of antiassociation activity of translation initiation factor 3 by paromomycin

The ribosome-recycling step: Consensus or controversy?

The role of ribosome recycling factor in dissociation of 70S ribosomes into subunits

Interaction of RRF and EF-G from E. coli and T. thermophilus with ribosomes from both origins - Insight into the mechanism of the ribosome recycling step

Inhibition of human T-cell leukemia virus type I by the short oligoguanylic acids in vitro

In vivo effect of inactivation of ribosome recycling factor - Fate of ribosomes after unscheduled translation downstream of open reading frame

The history of deciphering the genetic code: Setting the record straight

Release of Ribosome-bound Ribosome Recycling Factor by Elongation Factor G